According to the new findings, crystals become gallstone in gallbladder because of immune cells. This discovery was made while Martin Hermann and his colleagues at Friedrich-Alexander University Erlangen-Nurnberg in Germany was studying small stone in the bile of people undergoing treatment for gallstones.
Gallstones could be as small as a grain of sand or as huge as a golf ball. The symptoms could be abdominal pain, nausea, vomiting, and they are a leading cause of hospital admissions worldwide. In America surgery to remove Gallbladder is very common. There are several medicines to break down these stones, but it could take years or months.
“Neutrophils have long been considered the first line of defense against infection and have been shown to generate NETs that entangle and kill pathogens,” says senior study author Martin Herrmann, an immunologist at Universitätsklinikum Erlangen. “Here, we provide additional evidence for the double-edged-sword nature of these NETs by showing that they play an important role in the assembly and growth of gallstones. Targeting neutrophils and NET formation may become an attractive instrument to prevent gallstones in high-risk populations.” One of the major troubles for making a cure is because researchers are still not sure how gallstones are formed.
To get more proof that Neutrophil extracellular traps (NET) lead to the formation of gallstones, researchers spun and shook in the presence and absence of NET. In the presence, the gallstone surfaces quickly collected neutrophil DNA.
“The possibility of stopping these processes with new PAD4 inhibitors or with metoprolol—an established beta-blocker—may introduce new therapeutic strategies that avoid surgery,” Luis Muñoz of Universitätsklinikum says. “However, human studies are required to establish new therapies for gallstone disease. Hopefully, we can convince pharmaceutical companies to perform a clinical study with inhibitors of NET formation or NET aggregation.”
Metoprolol is currently used to treat people with heart disease. Test of these drugs in mice have shown a reduction of gallstones but trials in humans are required to conform for further proof.